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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiativePrecision medicine has been advocated by the majority of scientists and doctors.This article does not oppose precision medicine.However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords： precision medicine     personalized medicine     genomics    

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract:

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosisThey could also provide the ideal scheme to personalize treatment in precision medicine.

Keywords： liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

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Human pangenome: far-reaching implications in precision medicine

Frontiers of Medicine doi: 10.1007/s11684-023-1039-1

Abstract: Human pangenome: far-reaching implications in precision medicine
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Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 152-159 doi: 10.1007/s11684-017-0499-6

Abstract:

Medicine has encountered unprecedented problems associated with changes in nature, society, and environmentIn the meantime, the development of medicine is facing challenges that resulted from the over-divisionnew medical system that is more suitable for human health and disease treatment, holistic integrative medicineHIM is the inevitable and necessary direction for the future development of medicine.

Keywords： holistic integrative medicine     precision medicine     general practice     medicine    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract:

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discoveringcell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precisionmedicine.The future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical trials. However, the dose intensity of conventional chemotherapy has been pushed to its limit. Further improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno- and cellular-therapy approaches together with precise risk stratification. Children with or hyperdiploid>50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in treatment. Patients with Philadelphia chromosome (Ph)-positive or Ph-like ALL with ABL-class fusion should be treated with dasatinib. BH3 profiling and other preclinical methods have identified several high-risk subtypes, such as hypodiplod, early T-cell precursor, immature T-cell, -rearranged, Ph-positive and -positive ALL, that may respond to BCL-2 inhibitor venetoclax. There are other fusions or mutations that may serve as putative targets, but effective targeted therapy has yet to be established. For other high-risk patients or poor early treatment responders who do not have targetable genetic lesions, current approaches that offer hope include blinatumomab, inotuzumab and CAR-T cell therapy for B-ALL, and daratumumab and nelarabine for T-ALL. With the expanding therapeutic armamentarium, we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy     CAR T-cell therapy    

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Precision Burn Trauma Medicine: Application for Molecular Engineering Science

Kristen Jakubowski, Michael Poellmann, Raphael C. Lee

Engineering 2015, Volume 1, Issue 3,   Pages 280-281 doi: 10.15302/J-ENG-2015073

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 1-7 doi: 10.1007/s11684-012-0173-y

Abstract: Individualized treatment in modern medicine is mainly established based on individual genome informationChinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicineIt promotes the study of the relationship of each constitution to diseases and Chinese medicine preparationdisease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicinetreatment and health medicine for the international medical community.

Keywords： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2,   Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract:

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracyThe conception, applications and history of ultra-precision machining are introduced in this article,and the developments of ultra-precision machining technologies, especially ultra-precision grinding,ultra-precision cutting and polishing are also reviewed.

Keywords： ultra-precision grinding     ultra-precision cutting     ultra-precision polishing     research status in China     development    

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 163-170 doi: 10.1007/s11684-011-0143-9

Abstract: in clinical practice, but without the benefit of undergoing the experimental medicine stage.medicine to Chinese medicine is appearing.The rapid transition and transformation from experience medicine to evidence-based medicine have becomeimportant content in the development of Chinese medicine., as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine

Keywords： Chinese medicine     experience medicine     evidence-based medicine     real world    

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Organoid Technology and Clinical Applications in Digestive System Cancer Review

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Engineering 2022, Volume 9, Issue 2,   Pages 123-130 doi: 10.1016/j.eng.2021.04.017

Abstract: More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine developmentand their applications as a novel model in basic cancer research, preclinical medical practice, and precisionmedicine.

Keywords： Organoid     Digestive system cancer     Precision medicine    

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 348-353 doi: 10.1007/s11465-008-0065-7

Abstract: This paper presents the principle of self-generation of machining precision by explaining its basic conceptThe self-generation of machining precision for solid balls with super precision is emphatically explainedNecessary conditions for achieving self-generation of machining precision are given.Establishment of the system for machining solid balls with super precision is discussed.Self-generation of machining precision for solid balls with super precision on the basis of the capability

Keywords： self-generation     necessary     self-regulation capability     viewpoint     Necessary    

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine

Keywords： big data     traditional Chinese medicine     clinical evaluation     evidence based medicine    

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Title Author Date Type Operation

Do not let precision medicine be kidnapped

Zhiping Yang

Journal Article

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

Human pangenome: far-reaching implications in precision medicine

Journal Article

Holistic integrative medicine: toward a new era of medical advancement

Daiming Fan

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Precision Burn Trauma Medicine: Application for Molecular Engineering Science

Kristen Jakubowski, Michael Poellmann, Raphael C. Lee

Journal Article

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Journal Article

Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Journal Article

Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Journal Article

John Vaughn: Accessible MRI, the Future of Precision Medicine and Algorithm Based Radiology (2019-9-18

23 Aug 2021

Conference Videos

Organoid Technology and Clinical Applications in Digestive System Cancer

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Journal Article

Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article